Looking to get the most out of your alien arsenal? In this High on Life 2 guns guide, you’ll learn how to unlock every weapon and what makes each one special. From close-range monsters to puzzle-solving chaos tools, here’s how to use every gun properly and dominate every fight the game throws at you.
Table of Contents
Gus
- How to unlock: Available from the start of the game (first mission)
Gus is your go-to weapon in High on Life 2 when things get messy up close. He’s essentially a high-damage shotgun with a surprisingly steep skill curve. At first, his shots can feel a bit inaccurate, but once you understand his range and timing, he becomes one of the most satisfying guns to use.
In tight rooms and narrow corridors, Gus dominates. His close-range burst damage melts regular enemies in seconds. The real highlight, though, is his Trickshot disc launcher.
What makes Gus special:
- Massive close-range burst damage
- Lava discs that bounce and deal multiple hits
- Suction ability to pull enemies into your range
- Discs can create temporary platforms on certain walls
To maximize damage, fire a disc, then hit it mid-air with Knifey. This makes the disc bounce around, hitting enemies multiple times and turning one shot into a devastating combo.
Sweezy
- How to unlock: Available from the start (first mission)
Sweezy is your flexible all-rounder in High on Life 2. She feels like a weapon you can bring into almost any situation and make work. While she might not outclass the heavy hitters later on, she remains a reliable pick throughout the game.
Her default fire acts like a high-fire-rate SMG, perfect for sustained pressure. If you need precision, switch to her charged single shot, which hits much harder and works well at mid to long range.
What makes Sweezy special:
- Fast-firing SMG mode for constant damage
- Charged precision shot for tougher enemies
- Time Bubble Trickshot that slows enemies and objects
- Can hit switches through thin walls with piercing shots
Her Time Bubble is especially strong. It slows enemies in High on Life 2 for easy cleanup and is crucial in puzzle sections where timing matters.
Knifey
- How to unlock: Available from the very start
Knifey is your only true melee option in High on Life 2, and while he lacks any ranged attacks, he absolutely earns his place in your loadout.
He shines when enemies are staggered. Rush in to finish them off instantly or deal massive close-range damage to conserve ammo.
Why you should use Knifey:
- Powerful finisher on weakened enemies
- Great for conserving ammo
- Perfect panic option while reloading
- Some of the best dialogue in the game
He isn’t built to be your main weapon in High on Life 2, but as a secondary tool, Knifey is invaluable.
Sheath
- How to unlock: Complete the Senator Muppy Doo bounty
Sheath might have the most metal introduction in High on Life 2, and she absolutely lives up to it. This mid-range burst rifle feels smooth, precise, and incredibly satisfying for tactical players.
Her standard fire is a three-round burst, so you need to aim accurately and consider positioning. The lower sustained damage is offset by strong burst potential and smart ability usage.
What makes Sheath special:
- Accurate mid-range burst rifle
- Spike Trickshot that chains electric damage through enemies
- Creates ziplines for traversal
- Solves electrical circuit puzzles and door mechanics
Her Spike ability is the real highlight. Fire it into a group and watch electricity chain between enemies, creating Yondu-style chaos. It’s perfect for grouped targets and creative setups in High on Life 2.
Travis & Jan
How to unlock:
- Complete the Billionaire Larry Pinkstock bounty to get Travis
- Finish the dinner mission to recruit Jan
This chaotic duo might argue nonstop, but in combat, they are ridiculously strong. Travis and Jan are dual-wielded energy pistols that reward aggressive play and quick trigger fingers.
Both fire single shots, and the real trick is alternating your shots instead of spamming. If you get the rhythm right, you unleash a rapid chain of powerful hits that melts enemies faster than you might expect.
What makes Travis & Jan special:
- Extremely high damage output when alternating shots
- Surprisingly accurate hipfire-only weapons
- Jan’s explosive slime glob for extra burst damage
- Travis’ levitating glob to lift enemies and platforms
Travis alone already hits hard, but once Jan joins, the fun really begins. Their Trickshots provide both combat and puzzle utility. You can launch enemies into the air for easy follow-ups or raise platforms to clear obstacles.
Creature
- How to unlock: Interact with Creature during the Pick Up Jeppy mission
Creature is easily one of the weirdest weapons in High on Life 2. Instead of bullets, you launch screaming alien babies at your enemies. It’s chaotic, slightly disturbing, and surprisingly effective in the right situations.
In direct damage, Creature feels more niche compared to other guns. However, his real strength lies in crowd control and distraction.
What makes Creature special:
- Launches alien babies that attack enemies automatically
- Excellent crowd control when you feel overwhelmed
- Hypno Baby Trickshot that temporarily mind controls enemies
- Unique puzzle-solving mechanics outside of combat
If a fight in High on Life 2 starts spiraling out of control, spam babies. They distract enemies, deal chip damage, and give you breathing room. The Hypno Baby is even better, turning one enemy into a temporary ally.
B.A.L.L.
How to unlock:
- Find the three blue men in the open world
- Complete their side missions to restore the weapon
B.A.L.L. is a hidden gem in High on Life 2 and absolutely worth the effort. After teasing you with its broken shell for most of the game, finally unlocking it feels incredibly satisfying. This weapon is all about chaos and ricochets. It plays like a deadly pinball machine in your hands.
What makes B.A.L.L. special:
- Fires projectiles that ricochet around the arena
- Special ability drops a pinball-style bumper
- Perfect for crowded fights and tight spaces
- Extremely fun once you master the bounce angles
Set up the bumper, fire a shot into it, and watch the ball fly across the battlefield, smashing into enemies from unexpected angles. It takes a bit of practice to predict the bounces, but once it clicks, it becomes a crowd-shredding machine.
Bowie
- How to unlock: Complete the Finance Wiz James Stevenson mission
A bow in a game full of talking alien guns sounds underwhelming. But Bowie helps you land massive long-range hits in High on Life 2 that delete enemies before they even reach you.
Bowie fires slowly, and yes, aiming can feel a bit clunky at first. But if you take your time and line up your shots, the damage is incredible. A clean headshot often drops weaker enemies instantly, and tougher ones rarely survive a follow-up arrow.
What makes Bowie special:
- Huge single-shot damage at long range
- Strong opener before enemies close the gap
- Soul Hole Trickshot to reveal hidden weak points
- Essential for certain puzzles and boss mechanics
The Soul Hole is more than a gimmick. It lets you see hidden black-and-white objects and reveal weak spots you otherwise can’t hit. In some boss fights, it is absolutely crucial.
Shoot-O
How to unlock:
- Complete the mission that begins at Party City
- Fully unlocked during the Escape From Prison mission
Shoot-O changes how you approach combat in High on Life 2. Instead of traditional ammo, he lets you weaponize the environment. With his gravity power, you can grab objects from surprisingly far away and hurl them directly at enemies.
What makes Shoot-O special:
- Telekinetically grab and throw environmental objects
- Near unlimited range for picking up items
- Many objects act as one-shot kill projectiles
- Gravity ability usable without swapping weapons
Once you start flinging explosive barrels and debris across the arena, it’s hard to go back to normal shooting.
Upgrade Your High on Life 2 Guns with PLITCH!
If you want to fully experiment with every weapon, PLITCH’s High on Life 2 cheats give you complete control over the chaos. Test different playstyles without worrying about survival or managing ammo.
The most useful codes for a guns-focused run are:
- No Reload for nonstop shooting with Gus, Sweezy, or Travis and Jan
- Super Accuracy to make Bowie and Sheath even deadlier
- No Recoil for smoother burst and SMG control
- Easy Kills to shred enemies while testing Trickshots
- Unlimited Health for stress-free experimentation
You can also boost mobility with Set Player Speed, Set Jump Height, or Unlimited Jumps to create wild combat scenarios.
Whether you want pure power fantasy or just practice mastering each weapon, PLITCH lets you customize the experience your way.
If you want to learn more about PLITCH, check out this blog and our YouTube channel!
Happy Gaming!
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